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Studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. When B12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. It is during this first pass in its native form that it is believed to exert its therapeutic effect. CLINICAL RESEARCH: "The World Health Organization (WHO) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which IgE-mediated allergy may be involved."1 In 1988, asthma and allergic rhinitis subjects were treated with B12. Total IgE, specific IgE and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. Eight of the 9 subjects had reduced IgE. 2 In 1989 open label studies at two sites in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3

All of the active B12 group reporting showed reduction in severity of symptoms ranging from 31% to 70%, while the placebo controls reported either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 for IgE reductions. In 1992, the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to be in agreement that the statistics indicated a significant reduction in IgE and that a quantitative drop in symptoms was demonstrated. In 1992, Belen Anibarro, MD, studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The test was repeated after premedication with 1.5 mg of oral cyanocobalamin. In four of the five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6

Feeling fine in general, allergy symptoms improved. C. T. Have been doing a lot better. Lisa L. So far, so good. Andy G. Felt congested, but improved. Richard R. Feeling fine. No problems. Roland H. Feel OK as far as allergies. Angel P. I felt relief after the treatment, and still feeling better. A. V. I feel OK, but have a little congestion. Carlin R. Feel better than before. Art P. Feel good - continue with sinusitis Bob M. Feeling moderate. Gustavo M. Much better. Alejandro M. What Patients Said After More Than Two Months All my symptoms seem to have gone. Margareth Z. For the first time after taking the treatment, I felt like my life was my own. After 20 years I was able to go out in traffic and high winds with little or no bad effects. I could even tolerate gas lawn mowers. I was able to walk around without huffing and puffing. Pain in throat and lungs disappeared. Getting air in lungs.

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